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Testosterone, Gonadotropin, and Cortisol Secretion in Male Patients With Major Depression

Ulrich Schweiger, MD, Michael Deuschle, MD, Bettina Weber, MD, Andreas Körner, MD, Claas-Hinrich Lammers, MD, Jürgen Schmider, MD, Ulrike Gotthardt, MD and Isabella Heuser, MD

From the Max-Planck-Institute of Psychiatry, Clinical Institute, Munich, Germany.



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  		Fig. 1. Age and 24-hour testosterone secretion in men with major depression and a healthy comparison group. Linear regression analysis shows an absence of significant correlation between age and 24-hour testosterone secretion in the patient group (r = .11). In the comparison group there is a trend toward a negative correlation between age and 24-hour testosterone (r = -.39; p < .08). ANCOVA reveals significantly lower concentrations in depressed patients (df = 1,33; F = 8.5; p < .001) and a trend for an interaction between age and diagnosis (df = 1,33; F = 3.7; p < .07).

 


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  		Fig. 2. Age and 24-hour cortisol secretion in men with major depression and a healthy comparison group. Linear regression analysis shows an absence of significant correlation between age and 24-hour cortisol in the patient group (r = .26). In the comparison group there is a significant positive correlation between age and 24-cortisol (r = .56; p < .01). ANCOVA reveals significantly higher concentrations in depressed patients (df = 1,34; F = 93.5; p < .01) and a significant correlation with age (df = 1,34; F = 4,9; p < .05).

 


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  		Fig. 3. Relationship between 24-hour cortisol and 24-hour testosterone in men with major depression and a healthy comparison group. No significant correlation can be found between 24-hour cortisol and 24-hour testosterone concentrations in the two groups (patients r = -.17, comparison group r = -.33). When both groups are pooled there is a significant negative correlation (r = -.49; p < .01).

 




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