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Reduction of Natural Killer Cytotoxic Activity in Major Depression: Interaction Between Depression and Cigarette Smoking

Waymond Jung, MD and Michael Irwin, MD

From the Department of Psychiatry, University of California, San Diego, and Department of Psychiatry, San Diego VA Medical Center, San Diego, California.



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  		Fig. 1. Effects of depression and smoking on NK activity across the four effector-to-target cell ratios in control nonsmokers, control smokers, depressed nonsmokers, and depressed smokers. A pairwise comparison showed that depressed smokers had lower levels of NK activity than depressed nonsmokers (F = 7.8, p < .005).

 




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