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Apolipoprotein E Genotype and Temperament: A Longitudinal Study From Infancy to the Late Teens

From The Centre for Mental Health Research (A.F.J.), Australian National University, Canberra; Department of Psychology (M.P., A.S., D.S.), Royal Children’s Hospital/University of Melbourne, Melbourne; and the Centre for Bioinformation Science and John Curtin School of Medical Research (Y.Z., S.E.), Australian National University, Canberra, Australia.

Address reprint requests to: Anthony F. Jorm, PhD, DSc, Centre for Mental Health Research, Australian National University, Canberra, ACT 0200, Australia. Email: Anthony.Jorm{at}anu.edu.au

Received for publication May 31, 2002; revision received October 7, 2002.

OBJECTIVE: To replicate an earlier Finnish study by Keltikangas-Järvinen et al. (5) reporting that the APOE genotype is associated with temperamental traits involving increased activity.

METHODS: DNA was collected from 683 Australian children who had participated in a longitudinal study of childhood temperament from 4 to 8 months up to 17 to 18 years. Associations were examined between APOE genotype and a range of measures of activity and hyperactivity.

RESULTS: No associations were found.

CONCLUSIONS: The earlier Finnish finding could not be replicated despite adequate statistical power.

Key Words: apolipoprotein E, • temperament, • children, • activity.

Abbreviations: APOE = apolipoprotein E;; EAS = Emotionality Activity and Sociability;; PCR = polymerase chain reaction;; RBPC = Revised Behavior Problem Checklist;; SATI = School Aged Temperament Inventory;; STSI = Short Temperament Scale for Infants;; STST = Short Temperament Scale for Toddlers.

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