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Psychosomatic Medicine, Vol 47, Issue 1 46-57, Copyright © 1985 by American Psychosomatic Society

ORIGINAL ARTICLES

Pseudocyesis: psychologic and neuroendocrine interrelationships

MN Starkman, JC Marshall, J La Ferla and RP Kelch

There is a paucity of information concerning the interrelationship of psychiatric and neuroendocrine abnormalities in pseudocyesis. We have studied two patients using a multimodal investigatory approach, with particular attention to the association of depression and alterations in endocrine secretory patterns. Both patients had abnormal growth hormone secretory patterns, as demonstrated by lack of sleep-associated peaks and the absence of a response to L-dopa administration. Both patients had elevated testosterone and estradiol levels and normal prolactin levels. Only the patient who met DSM III criteria for a major depressive episode had abnormally elevated luteinizing hormone (LH) levels and large LH pulse amplitudes. These findings, together with a review of cases reported in the literature, suggest that no single neuroendocrine profile is common to all patients with pseudocyesis.




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Copyright © 1985 by the American Psychosomatic Society