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Psychosomatic Medicine 36:304-310 (1974)
© 1974 American Psychosomatic Society

Plasma Dopamine-beta-hydroxylase (DBH) Activity During the Menstrual Cycle

FRIEDHELM LAMPRECHT MD1, RAYMOND J. MATTA MD1, BETSY LITTLE AB1, and THEODORE P. ZAHN PHD1

1 Laboratory of Clinical Science and Laboratory of Psychology, Department of Health, Education and Welfare, National Institute of Mental Health, Bethesda, Maryland, 20014

Plasma DBH activity was measured in 6 women, 6 days a week, over a complete menstrual cycle. The women rested for 1/2 hour before giving blood samples. DBH was assayed by a double enzymatic method. It was found that DBH activity increased during the follicular phase of the cycle, reaching a peak soon after ovulation, then decreased to a minimum during the premenstrual period. The activity of this enzyme does not seem to parallel the levels of estrogen or progesterone, nor those of peripheral indicators of autonomic activity such as skin conductance and heart rate, but the mood "Surgency" showed comparable changes over the cycle.

Submitted on August 23, 1973
Revised on December 12, 1973






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Copyright © 1974 by the American Psychosomatic Society